BIOGRID CURATED DATA FOR HXK2 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for HXK2 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication

蛋白质-蛋白质、遗传以及化学相互作用数据集，针对Saccharomyces cerevisiae（S288c）中的HXK2（己糖激酶同工酶2）由BioGRID（https://thebiogrid.org）编纂；定义：己糖激酶同工酶2，催化细胞质中葡萄糖的磷酸化；在葡萄糖生长期间为主要的己糖激酶；在细胞核中发挥作用，以抑制HXK1和GLK1的表达并诱导其自身基因的表达；具有抗凋亡作用；由Snf1p蛋白激酶和Glc7p-Reg1p蛋白磷酸酶介导的丝氨酸-14位的磷酸化/去磷酸化调节Hxk2p的核质穿梭；HXK2具有一个同源物HXK1，该同源物由全基因组倍增产生。