Research progress on attenuating toxicity and enhancing efficiency of <italic>Tripterygium wilfordii</italic> preparations against reproductive toxicity based on multi-omics technology and network pharmacology

Tripterygium wilfordii preparation has a significant effect in the treatment of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, but its reproductive toxicity greatly limits its clinical application. Multiomics technologies (genomics, transcriptomics, proteomics, metabolomics)can systematically analyze the mechanism of reproductive toxicity at the molecular level, and network pharmacology can construct a regulatory network of 'toxic componentscore targets-key pathways'. The combination of the two provides a new way to clarify the mechanism of reproductive toxicity of Tripterygium wilfordii and to study the strategy of reducing toxicity and increasing efficiency. This paper systematically reviews the material basis and mechanism of reproductive toxicity of Tripterygium wilfordii, and focuses on the application progress of multi-omics technology and network pharmacology in the mechanism analysis of reproductive toxicity of Tripterygium wilfordii and the strategy of reducing toxicity and increasing efficiency, aiming to provide reference for the clinical safe use of Tripterygium wilfordii preparations and the development of new low-toxic preparations.