Statistical significance of the spectratype differences between infected and control groups (A) or between infected groups for different isotypes (B), for each VH family.

1Adjusted p-values by a Benjamini-Hochberg correction for multiple testing of an empirical Bayesian test (H0 = “perturbation” index similar in the two groups). p-values indicating a significant difference between the tested groups (Type I error level = 0.01) are in bold. For more details, see M.&M., section “CDR3 length spectratyping analysis.