Effect of neurotensin on fed and fasted mouse livers

Neurotensin(NTS), a gut hormone, is known to impact whole body energy metabolism. Here we investigated the impact of neurotensin on the liver in fed (ad libitum) and fasted (22h) female mice livers from NTS wild type (WT) and knockout (KO) mice. Our goal was to investigate the regulation of energy metabolism pathways in the liver that are regulated by neurotensin, specifically lipid uptake and mitochondrial metabolism. RNAseq profiling of livers from NTS WT and KO mice that were either fed (ad-libitum) or fasted for 22h. There were 3 mice in each group.