Mycobacterium tuberculosis Genome sequencing and assembly
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP262684
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资源简介：
The aim of this study was to identify on-target inhibitors of Mycobacterial Membrane Protein Large 3 (MmpL3) , a member of Resistance Nodulation and Division Transporters of Mycobacterial tuberculosis from GSK Tres Cantos Anti-Mycobacterial Set. The cell-based assay identified a guanidine CCI7967 to target MmpL3. CCI7967-resistant mutants harbored mutations that mapped to MmpL3, futher confirming it's on target activity. The cell-based assay developed for this study could be used to identify new MmpL3-specific scaffolds and rapidly screen for optimized analogues to facilitate their development as potent anti-tuberculars.
创建时间：
2021-06-30
