Thiazolyl Phosphine Ligands for Copper-Catalyzed Arylation and Vinylation of Nucleophiles in Organic and Aqueous Media

A straightforward and efficient synthetic route to thiazolyl phosphines is reported. Moreover, the first application of these molecules in catalysis is described. These phosphines are excellent ligands in the copper-catalyzed arylation and vinylation of nucleophiles. The reactions could be performed in acetonitrile and various mixed aqueous/organic solvents and even in pure water in the presence of a phase transfer catalyst. In each case, coupling products are obtained with high yields at very mild temperatures.