Crystallization of feline coronavirus Mpro with GC376 reveals mechanism of inhibition

NIAID Data Ecosystem2026-05-02 收录

冠状病毒抑制剂

结构生物学药物发现

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Crystallization of feline coronavirus Mpro with GC376 reveals mechanism of inhibition

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2024-11-06

Structure of SARS-CoV-2 3CL protease in complex with the cyclopropane based inhibitor 1c

冠状病毒抑制剂

抗病毒药物结构与结合机制

Structure of SARS-CoV-2 3CL protease in complex with the cyclopropane based inhibitor 1c Descriptor: 3C-like proteinase, N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-({[(1R,2R)-2-pheny

Protein Data Bank Japan2024-11-20 更新100

PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z31432226

结构生物学药物发现

抗生素靶点

PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z31432226 Descriptor: (azepan-1-yl)(2H-1,3-benzodioxol-5-yl)methanone, 3-oxoac

Protein Data Bank Japan2025-05-07 更新50

Glycogen Synthase Kinase 3 beta Complexed with BRD0209

抑制剂设计

结构生物学药物发现

Glycogen Synthase Kinase 3 beta Complexed with BRD0209 Descriptor: (4~{S})-3-cyclopropyl-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta Autho

Protein Data Bank Japan2024-10-09 更新40

Specific covalent inhibitor of ERK2

抑制剂设计

结构生物学药物发现

Specific covalent inhibitor of ERK2 Descriptor: 1,2-ETHANEDIOL, 1-[(2~{S})-2-(5-methyl-3-pyridin-4-yl-1~{H}-pyrazol-4-yl)pyrrolidin-1-yl]propan-1-one, DIMETHYL SULFOXIDE, ... Authors: Cleasby, A. Depo

Protein Data Bank Japan2024-11-13 更新50

Crystal structure of PI3Kalpha selective Inhibitor 11-1575

PI3K抑制剂设计

结构生物学药物发现

Crystal structure of PI3Kalpha selective Inhibitor 11-1575 Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, tert-butyl (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(m

Protein Data Bank Japan2024-04-03 更新50

Crystallization of feline coronavirus Mpro with GC376 reveals mechanism of inhibition

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