Supplementary Material for: Study Of Leptin And Adiponectin Among Indian Older Adults With Mild Cognitive Impairment: Initial Experience Of Memory Clinic From A Geriatric Tertiary Care Center In India

Introduction We aim to report the prevalence of Mild cognitive impairment (MCI) among healthcare-seeking Indian older adults and study the relationship between serum leptin and adiponectin with MCI. Methods This cross-sectional study, conducted in a tertiary care centre's Memory Clinic in India, utilized Clinical Dementia Rating (CDR) for patient categorization. Patients with a CDR of 0.5 were diagnosed with MCI, excluding those with a CDR >1. Biochemical markers, including leptin and adiponectin, were measured using ELISA. Results During the study period of two years, 163 patients were included. Among them, 84 (52%) had MCI, and 58 (69%) had amnestic MCI. Patients with MCI were older (69.4 vs 67.4, p=0.048) and more prevalent in males [29 (72.50%) vs 11 (44.72%), p=0.002]. Education and socio-economic status were associated with MCI. Among comorbidities and geriatric syndromes, multi-morbidity (OR: 7.35; 95%CI 3.44-15.69), diabetes (OR: 2.65; 95%CI 1.25-5.63), cerebrovascular accident (OR: 27.68; 95%CI 6.18-124.06), chronic obstructive pulmonary disease (OR: 4.77; 95%CI 2.11-10.76), coronary artery disease (OR: 6.64; 95%CI 2.30-19.12), and urinary incontinence (OR: 5.63; 95%CI 2.25-14.11) were associated with MCI. Adiponectin was significantly lower in patients with MCI (1.36 vs 2.50, p=0.003), whereas serum leptin was higher (2.56 vs 2.46, p=0.827) but not significant after adjusting for age, sex, diabetes and coronary artery disease. Conclusion In healthcare-seeking older patients MCI is prevalent and low serum adiponectin may serve as a valuable marker. Addressing multi-morbidity early at the primary care level could be a promising strategy for preventing dementia.