Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans.

In this study we compared the transcriptomic profile in control L3 larvae with that of mild or strong (arrested) nuo-5 RNAi. The two treatment (mild and strong) in fact lead to two very different phenotype. The mild supperssion of nuo-5 induces improved healthspand and has pro longevity effect. The strong suppression of the same gene has, on the contrary, deleterious effects such as arrested development.本研究将对照组第三期幼虫（L3 larvae）的转录组谱（transcriptomic profile），与经轻度或重度（发育停滞型）nuo-5 RNA干扰（RNAi）处理的样本进行了对比。两类处理方式实则会引发两种截然不同的表型（phenotype）：轻度抑制nuo-5基因可提升健康寿命（healthspan），并发挥促长寿效应；而重度抑制该基因则会产生有害影响，例如导致发育停滞。