Human WRN helicase in complex with allosteric ligand Compound 1

Human WRN helicase in complex with allosteric ligand Compound 1 Descriptor: 2-[(9R)-1'-[(1,3-benzoxazol-2-yl)acetyl]-2-(morpholin-4-yl)-8-oxo-5,8-dihydro-4H-spiro[furo[3,4-d][1,2,4]triazolo[1,5-a]pyrimidine-7,4'-piperidin]-4-yl]-N-[2-chloro-4-(trifluoromethyl)phenyl]acetamide, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION Authors: Palte, R.L, Koglin, M, Maskos, K, Tauchert, M.J. Deposit date: 2025-06-02 Release date: 2025-09-10 Last modified: 2025-09-17 Method: X-RAY DIFFRACTION (2.34 Å) Cite: High-throughput evaluation of novel WRN inhibitors. Slas Discov, 35, 2025