Probing endogenous protein localization and function in vivo remains challengingdue to laborious gene targeting and monofunctional alleles. Here, we develop amultifunctional and adaptable toolkit base

NIAID Data Ecosystem20

GFP-on mouse model for interrogation of in vivo gene editing

体内基因编辑模型

碱基编辑器

The development of Cas9 technology has spurred advances in in vivo treatments, offering promising avenues for targeted gene editing within living organisms. However, the challenge of efficient and spe

NIAID Data Ecosystem00

A new class of genome rare cutters.

基因编辑工具

DNA大片段切割

Although significant efforts have been directed at developing efficient techniques for rare and super rare genome cutting, only limited success has been achieved. Here we propose a new approach to sol

PubMed Central1996-07-01 更新20

Cryo-EM structure of Crt-SPARTA-gRNA-tDNA dimer (conformation-1)

冷冻电镜结构解析

基因编辑工具

Cryo-EM structure of Crt-SPARTA-gRNA-tDNA dimer (conformation-1)

NIAID Data Ecosystem20