Differential DNA methylation in the benign and cancerous prostate tissue of African American and European American men

The data presented here are the summary statistics for the manuscript, "Differential DNA methylation in the benign and cancerous prostate tissue of African American and European American men." The study aims to improve our understanding of prostate cancer disparities between African American and European American men by comparing the DNA methylation features that distinguish tumor and paired, histologically benign tissue from a sample of African American and European American prostate cancer patients. The summary statistics presented here represent the results of a differential methylation analyses comparing tumor and benign tissue in each ancestry group as well as the results of an analysis of differential methylation by ancestry group within each tissue.  

The files included are: 

AA_TumorvBenign_Dummy.zip which contains the results of the association analysis between tumor vs benign (benign as the default) tissue status and individual CpG sites in African Americans based on a model that accounts for the paired nature of samples using a series of dummy variables for individual. 

AA_TumorvBenign_MixedModel.zip which which contains the results of the association analysis between tumor vs benign (benign as the default) tissue status and individual CpG sites in African Americans based on a model that accounts for the paired nature of samples using a linear mixed model that included patient as a random effect. 

EA_TumorvBenign_Dummy.zip which contains the results of the association analysis between tumor vs benign (benign as the default) tissue status and individual CpG sites in European Americans based on a model that accounts for the paired nature of samples using a series of dummy variables for individual. 

EA_TumorvBenign_MixedModel.zip which which contains the results of the association analysis between tumor vs benign (benign as the default) tissue status and individual CpG sites in European Americans based on a model that accounts for the paired nature of samples using a linear mixed model that included patient as a random effect. 

Benign_AncestryCompare_Summary.zip which contains the results of an association analysis between ancestry designation (African American vs European American with African American as the baseline) and individual CpG sites in benign tissue. 

Tumor_AncestryCompare_Summary.zip which contains the results of an association analysis between ancestry designation (African American vs European American with African American as the baseline) and individual CpG sites in tumore tissue.