DJ-1 is dispensable for human stem cell homeostasis
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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our data showed that the absence of DJ-1 had no adverse effects on proliferation, differentiation, and oxidative stress responses of human stem cells such as hNSCs and hMSCs as well as hVECs, suggesting that loss of DJ-1 function alone is insufficient to disrupt the homeostasis of these human cells. In addition, we found that CHCHD2 was upregulated upon DJ-1 deficiency, which may account for the absence of severe phenotypes in various types of DJ-1-deficient cells. For the first time, our study revealed the 'see-saw' expression pattern of two Parkinsonâs disease-associated genes, providing potential clues for understanding the mechanisms of DJ-1- and CHCHD2-associated Parkinsonâs disease.
提供机构：
State Key Laboratory of Stem Cell and Reproductive Biology
创建时间：
2022-02-20
