Inactivation of BCL11A reactivates silenced human HbF in adult mice
收藏官方服务：
资源简介：
Inactivation of BCL11A reactivates silenced human HbF in adult mice
应用场景：
创建时间：
2012-12-19
相关数据集
Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies [4C]
We have identified putative repressor region (PRR) to exon-1 of β-globin (βE1) in the β-globin cluster as a core region in alll the HPFH deletions that activates fetal hemoglobin and silences adult he
NIAID Data Ecosystem100
Reactivation of Zeta-Globin by deletion of BCL11A and LRF in HUDEP cells (ATAC-seq)
The alpha and beta-globin loci harbour genes that are expressed during development and silenced throughout post-natal life. Learning to reactivate these genes may offer new therapeutic approaches for
NIAID Data Ecosystem40
Base editing of key residues in the BCL11A-XL-specific zinc finger domains de-represses fetal globin expression
Evaluating the effect of disrupting the ZnF domains in BCL11A-XL isoform in erythroid lineage and also in engraftment potential of the edited HSPCs
NIAID Data Ecosystem30
Reactivation of Zeta-Globin by deletion of BCL11A and LRF in murine cells. Reactivation of Zeta-Globin by deletion of BCL11A and LRF in murine cells
The alpha and beta-globin loci harbour genes that are expressed during development and silenced throughout post-natal life. Learning to reactivate these genes may offer new therapeutic approaches for
NIAID Data Ecosystem40
In vivo base editing by a single intravenous vector injection for the treatment of hemoglobinopathies
Individuals with beta-thalassemia or Sickle Cell Disease and hereditary persistence of fetal hemoglobin (HPFH) possessing 30% HbF appear to be symptom-free. Here, we used a non-integrating HDAd5/35++
NIAID Data Ecosystem30
