Erythropoietin activates Phospholipase C gamma (PLCG)

PLCG1 (Phospholipase C gamma1) or PLCG2 bound to the activated EPOR is phosphorylated on tyrosine residues by the kinase LYN (Ren et al. 1994, and inferred from mouse homologs). PLCG1 and PLCG2 produce inositol 1,4,5-trisphosphate which then activates calcium signaling, and diacylglycerol (DAG) which then activates protein kinase C (PKC).

PLCγ1（磷脂酰肌醇特异性磷脂酶C γ1）或PLCγ2与活化后的EPOR结合后，在LYN激酶（Ren等，1994年，以及从小鼠同源基因推断）的作用下在酪氨酸残基上发生磷酸化。PLCγ1和PLCγ2产生肌醇1,4,5-三磷酸，进而激活钙信号传导，以及二酰甘油（DAG），随后激活蛋白激酶C（PKC）。