Means and Standard Deviations of the MR imaging analyses and polysomnographic parameter.

There were no differences of brain tissue volumes between both patient groups or between FD patients and healthy controls. Values of lesion load did also not differ between both patient groups (two-sample t-tests).Patients with CSA-CSR showed significantly decreased sleep efficiency, a higher AHI and cAHI, and a more severe oxygen desaturation compared to patients without CSA-CSR. Four patients with OSAS were found, two in both patient groups.P-values in bold indicate significant differences between both patient groups.Sleep Efficiency = total sleep time/total recording time ×100; Sleep stages: 1 = alpha rhythm is attenuated and replaced by low amplitude, mixed frequency for more than 50% of the epoch; 2 = presence of sleep spindles and K complexes on a background of low-amplitude, mixed frequency activity; 3 = slow wave activity in greater than 20% [2]. FD = Fabry Disease; CSA = Central Sleep Apnea; WM = White Matter; GM = Gray Matter; WML = White Matter Lesion; REM = Rapid Eye Movements; NREM = Non-REM; AHI = Apnea/Hypopnea Index; cAHI = central AHI; oAHI = obstructive AHI; SpO2 = Saturation of peripheral Oxygen; PLMS = Periodic Limb Movement; CRS = Cheyne-Stokes Respiration; CSR rel. = duration of CSR episodes/total duration of sleep.