Climber: a non-linear protein trajectory morphing method

We present a new morphing method that does not move linearly and can therefore go around high energy barriers, and which can produce different trajectories between the same two starting points. The input are two protein conformations (an initial and final conformation) and an alignment that will define which inter-residue distances are restrained to reach the final structure. <br/><br/>This project includes the following software/data packages: <br/> <ul> <li> <a href="https://simtk.org/frs?group_id=329#pack_989">Climber_v1.0 2011 Release </a> : This is an updated release needed to run Climber. Download Climber_v1.0_2010.tgz and unzip the file. Use the README file to run the examples. </li> <li> <a href="https://simtk.org/frs?group_id=329#pack_585">README </a> : readme file contains instructions to install the Climber executable, instructions to use the scripts and two examples </li> </ul>

本报告提出一种新型的变形方法，该方法非线性移动，因而能够绕过高能势垒，并能在相同的两个起始点之间产生不同的轨迹。输入数据包括两种蛋白质构象（初始构象和最终构象）以及一种对齐方式，该对齐方式将定义哪些残基间的距离受到限制以达到最终结构。本项研究包含以下软件/数据包：

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<li><a href="https://simtk.org/frs?group_id=329#pack_989">Climber_v1.0 2011 版本发布 </a>：这是运行 Climber 所需的更新版本。请下载 Climber_v1.0_2010.tgz 并解压文件。使用 README 文件运行示例。</li>
<li><a href="https://simtk.org/frs?group_id=329#pack_585">README </a>：readme 文件包含安装 Climber 可执行文件、使用脚本的说明以及两个示例。</li>
</ul>