The effect of probiotics supplementation on gut microbiota after Helicobacter pylori eradication: a multicenter, randomised controlled trial. The effect of probiotics supplementation on gut microbiota after Helicobacter pylori eradication: a multicenter, randomised controlled trial

AbstractBackground: Helicobacter pylori eradication therapy may lead to the perturbation of gut microbiota. We aim to investigate impact of probiotics on eradication rate and gut microbiota during eradication therapy. Methods: 162 patients receiving bismuth quadruple therapy were enrolled and randomly assigned to groups given probiotics (n=83) or placebo (n=79) for 4 weeks. Faecal samples were collected before treatment and 2 weeks, 4 weeks, 6 weeks, and 8 weeks after eradication therapy. Gut microbiota was analyzed by 16S rRNA high-throughput sequencing.