Demographic and clinical features of the WD patients.
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Demographic and clinical features of the WD patients.
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2015-12-03
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Wilson disease: intersecting DNA methylation and histone acetylation mechanisms affect gene expression regulation in a mouse model of hepatic copper accumulation [ChIP-Seq]. Wilson disease: intersecting DNA methylation and histone acetylation mechanisms affect gene expression regulation in a mouse model of hepatic copper accumulation [ChIP-Seq]
Prior investigations of DNA methylation differences in WD liver and blood and in a WD mouse model revealed an epigenetic signature of WD that included the histone deacetylase, HDAC5. To test the hypot
NIAID Data Ecosystem30
Table 2_Integrated proteomics and single-cell transcriptomics reveal potential therapeutic targets in Wilson’s disease patients.xlsx
PurposeWilson’s Disease (WD), an autosomal recessive ATP7B mutations disorder causing copper accumulation, poses diagnostic challenges. This study used proteomics and single-cell transcriptomics to id
NIAID Data Ecosystem10
Transcriptome profile of ATP7B KO cells and WT cells treated with Copper (Cu) to study Autophagy as a pro-survival mechanism in Wilson disease. Transcriptome profile of ATP7B KO cells and WT cells treated with Copper (Cu) to study Autophagy as a pro-survival mechanism in Wilson disease
To understand whether hepatic cells use autophagy to defend against Cu toxicity in WD, we employed ATP7B knockout (ATP7B-KO) HepG2 cell line, by Quant-seq experiments. Transcriptome analysis of the of
NIAID Data Ecosystem10
Wilson disease: intersecting DNA methylation and histone acetylation mechanisms affect gene expression regulation in a mouse model of hepatic copper accumulation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
NIAID Data Ecosystem30
Clinical, biochemical and genetic profile of WD patients in the S family.
aScreening refers to genetic screening of the ATP7B gene exons' by PCR followed by sequencing; bFew years later developed liver cirrhosis and portal hypertension;Normal ranges of: Serum ceruloplasmin:
Figshare2015-12-02 更新10
