A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, and Bevacizumab to Gemcitabine, Cisplatin, and Placebo in Patients With Advanced Transitional Cell Carcinoma

This randomized phase III trial studies gemcitabine hydrochloride, cisplatin, and bevacizumab
to see how well they work compared with gemcitabine hydrochloride and cisplatin in treating
patients with urinary tract cancer that has spread to other places in the body. Drugs used in
chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop
the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by
stopping them from spreading. Immunotherapy with bevacizumab, may induce changes in body's
immune system and may interfere with the ability of tumor cells to grow and spread. It is not
yet known whether gemcitabine hydrochloride and cisplatin are more effective when given with
or without bevacizumab in treating patients with urinary tract cancer.