Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by inorganic phosphate with istaroxime

Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by inorganic phosphate with istaroxime Descriptor: (3E,5S,8R,9S,10R,13S,14S)-3-(2-azanylethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C. Deposit date: 2022-02-16 Release date: 2022-04-27 Last modified: 2026-03-04 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids. Proc.Natl.Acad.Sci.USA, 119, 2022