Thyroid stimulating hormone (TSH) signaling pathway

Human thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-thyroid by stimulating production and secretion of the thyroid hormone from the thyroid gland. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the NetPath website until the pathway is published.

人类促甲状腺激素（TSH）是由垂体前叶分泌的一种糖蛋白激素，它在调节下丘脑-垂体-甲状腺系统中扮演着至关重要的生理角色，通过刺激甲状腺分泌甲状腺激素来实现其功能。TSH与TSH受体结合，该受体属于G蛋白偶联受体超家族的膜整合蛋白。TSH通过多种信号级联反应发挥作用，如cAMP级联反应和磷脂酶Cβ介导的肌醇磷酸生成。此外，它还将信号传递至NF-κB、有丝分裂原激活的蛋白激酶、蛋白激酶C模块。NetPath（http://www.netpath.org）是约翰霍普金斯大学PandeyLab（http://pandeylab.igm.jhmi.edu）与生物信息学研究所（http://www.ibioinformatics.org）之间的合作项目。若使用本通路，请在通路发表之前引用NetPath网站。