A Study of Roundup-Induced Gut Dysbiosis, Irrelevant to Aromatic Amino Acid Deficiency, Impairs the Gut Function in Rats, Tianchi Duan et.al.

We evaluated the impacts of chronic exposure to Roundup on gut health with the addition of AAA and explored the mechanism behind Roundup-induced gut dysfunction by performing fecal microbiota transplantation. 500 mg/kg·bw of Roundup, irrelevant to AAA deficiency, caused severe damage to gut function, as characterized by gut microbial dysbiosis, oxidative stress damage, intestinal inflammation and histopathological injury, particularly in female rats. Notably, similar to Roundup, Roundup-shaped gut microbiome evidently damaged serum, cecum and colon profiling of oxidative stress biomarkers (MDA, GSH-Px, SOD, GSSG and H2O2). Moreover, it induced 0.65-fold, 3.29-fold and 2.36-fold of increases in colonic IL-1β, IL-6 and TNF-α levels, and 0.34-fold of decrease in IL-10 level. Upon transplanting healthy fecal microbiota to Roundup-treated rats, they exhibited a healthier gut microenvironment with mitigated inflammation, oxidative damage and intestinal injury.