Wangjie Pig ALF Proteomics
收藏中国科技资源共享网2026-04-27 更新2026-01-30 收录
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https://escience.org.cn/metadata/detail?cstrId=CSTR:17970.11.A001G.202003.000895&id=774e74221ac511e980780242ac120006:CSTR:A0006.11.A001G.202003.000895
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资源简介：
Acute liver failure (ALF) is a fatal condition hallmarked by rapid development. The present study aimed to describe the dynamic alterations of serum proteins associated with ALF development, and to seek for novel biomarkers of ALF. Miniature pigs (n = 38) were employed to establish ALF models by infusing d-galactosamine (GALN, 1.3 g/kg). A total of 1310 serum proteins were compared in pooled serum samples (n = 10) before and 36 h after GALN administration through label-free quantitation (LFQ) based shotgun proteomics. Functional analysis suggested a significant enrichment of ALF-related proteins involved in energy metabolism. Temporal changes of 20 energy metabolism related proteins were investigated in individual pigs (n = 8) via parallel reaction monitoring (PRM) based targeted proteomics.
提供机构：
国家人口健康科学数据中心
创建时间：
2020-11-24
