Effect of iodine on early stage thyroid autonomy

Iodine slows TSH effects on thyroid growth stimulation and this effect is more pronounced in thyrocytes with constitutive cAMP activation i.e. in thyroid autonomy. Iodine induced growth alteration in early stage thyroid autonomy is conferred by induction of apoptosis and G2/M arrest. Transcriptome analysis revealed significant modulation of gene networks relevant to cell adhesion, cadherin signalling and ion binding with more pronounced effects in constitutively active FRTL-5 cells compared to normal FRTL-5 cells.碘可减缓促甲状腺激素（Thyroid-Stimulating Hormone, TSH）对甲状腺生长的刺激作用，且该效应在存在组成型环腺苷酸（cyclic adenosine monophosphate, cAMP）激活的甲状腺滤泡细胞中更为显著，即甲状腺自主性状态下。碘诱导的早期甲状腺自主性生长改变，由细胞凋亡诱导及G2/M期阻滞介导。转录组（Transcriptome）分析显示，与正常FRTL-5细胞相比，组成型激活的FRTL-5细胞中，与细胞黏附、钙粘蛋白信号通路及离子结合相关的基因网络受到显著调控，且该调控效应更为突出。