Bronchoalveolar lavage fluid and blood from human lung transplant recipients Metagenome

This exploratory study characterized the temporal and body-compartment-specific adaptation of eukaryotic viruses after lung transplantation in human patients. To investigate whether the donor-derived virome affects the recipient virome in other body-compartments and to identify ecological dependencies among different virus species, we used dat amodeling to analyse viral abundances in BALF and plasma at different time points after surgery. In summary, our analysis of virome dynamics after lung transplantation revealed host, body compartment and time-specific dependency patterns among viruses. Furthermore, our results suggested genetic adaptation to the host microenvironment at the level of the virome and support the hypothesis of functional complementarity between Anellovirus groups and other persistent viruses.