Gene expression and BCR data of bone marrow B cells in ITP
收藏DataCite Commons2025-01-23 更新2025-05-07 收录
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https://figshare.com/articles/dataset/Gene_expression_and_BCR_data_of_bone_marrow_B_cells_in_ITP/28260560/1
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资源简介：
Immune thrombocytopenia (ITP) is characterized by overproduction of anti-platelet autoantibodies through elusive mechanisms. Here, we investigated how central B-cell tolerance mechanisms affect autoantibody production in ITP. Our study employed integrative single-cell RNA and BCR sequencing (scRNA/BCR-seq) to systematically characterize the immunoglobulin (IG) repertoire across different developmental stages in bone marrow B cells. Notably, we discovered reduced receptor editing within IG kappa (IGK) genes, a critical process ensuring B cell tolerance.
提供机构：
figshare
创建时间：
2025-01-23
