Supplementary Material for: Sex Related Differences in Transcatheter Mitral Valve Repair: A Systematic Review and Meta-analysis

Objective: Inequalities in postoperative outcomes between males and females are well described with females often experiencing inferior outcomes after heart valve surgery. Recent literature has demonstrated equivalent or improved outcomes for females after transcatheter aortic valve replacement. Transcatheter mitral valve repair (TMVr) and replacement (TMVR) is a relatively newer field with significantly less literature comparing sex differences. This systematic review and meta-analysis looks to provide a comprehensive summary of the published literature comparing outcomes between males and females undergoing transcatheter MV interventions. Methods: PubMed, Medline, and Scopus were systematically searched for all studies comparing outcomes between males and females undergoing TMVr and TMVR. 2,178 English manuscript titles and abstracts were reviewed. Articles were excluded if data was not provided regarding sex differences, transcatheter MV intervention, full-length text was not accessible, or if insufficient data was provided. 2,170 articles were excluded and 8 articles were included in this study. Results: Pooled estimates of outcomes demonstrated rates of acute kidney injury [OR 1.28 (95% CI, 1.14-1.44; p<0.0001)] favored females while rates of major bleeding favored males [OR 0.85 (95% CI 0.76-0.96; p=0.01)]. Rates of mortality, postoperative MI, and stroke did not differ significantly. Conclusion: A trend has emerged in heart valve interventions with males tending to have improved outcomes after surgical intervention and females experiencing equivalent or improved outcomes after transcatheter interventions. This meta-analysis identified increased rates of acute kidney injury for males, increased rates of major bleeding for females, and otherwise comparable morbidity and mortality in males and females undergoing TMVr.