Inhibition of epigenetic modifiers LSD1 and HDAC1 blocks rod photoreceptor death in mouse models of Retinitis Pigmentosa.
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https://www.ncbi.nlm.nih.gov/sra/SRP311963
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资源简介：
In retinitis pigmentosa mouse models inhibitors of histone modification enzymes LSD1and HDAC1 blocked rod degeneration, preserved vision and affected the expression of multiple genes including maintenance of rod-specific transcripts and downregulation those involved in inflammation, gliosis and cell death. Overall design: Total 11 samples of mouse retina at PN24: 2 wild type controls C57Bl/6J, 3 rd10 B6.CXB1-Pde6brd10/Jrd10, 3 wild type treated with GSK2879552 (LSD1 inhibitor) from PN9 till PN24 and 3 rd10 treated with GSK2879552 from PN9 till PN24
创建时间：
2021-08-12
