Elevated numbers of infiltrating eosinophils accelerate the progression of Duchenne Muscular Dystrophy pathology in mdx mice.

Eosinophils are implicated in the development of many chronic diseases. However, their function in muscular dystrophy is understudied. Here we demonstrate that muscle hyper-eosinophilia could be a marker of poor outcomes in Duchenne Muscular Dystrophy. Overall design: To assess the effect of hyper-eosinophlia on muscle homeostasis, regeneration, and repair, SiglecF+ cells from WT and IL-5Tg mice were sorted from damaged muscles and subjected to RNAseq