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The intrinsically disordered region of SPIN1 regulates its function by phase separation [ChIP-seq]

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP402398
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As a transcriptional coactivator, SPIN1 has been reported to bind to chromatin.To assess the effect of IDR on chromatin binding, we investigated genome-wide chromatin association of SPIN1-WT or SPIN1-?IDR stably overexpressed cell lines by chromatin immunoprecipitation followed by high-throughput sequencing. Overall design: Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for the histone modifications H3K4me3 and FLAG in overexpression-Vector ,overexpression-SPIN1-WT or overexpression-SPIN1-?IDR SGC7901 cells.
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2024-12-20
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