ErbB (1-4) Receptor Signaling

This is a comprehensive, multi-scale model of ErbB receptor signal transduction in human mammary epithelial cells. This model, constructed manually from published biochemical literature, consists of 245 nodes representing proteins and their post-translational modifications sites, and over 1,000 biochemical interactions. The model also contains a number of commonly expressed receptor signaling pathways, including ErbB (1-4), EGFR endocytosis and recycling, G-protein-coupled receptor (alpha i, alpha q, alpha 12/13, and alpha s ligands), integrin, e-cadherin, and stress pathways.