Diabetes induces exacerbated SARS-CoV-2 replication partly associated with ineffective pulmonary interferon responses, delayed cell-mediated immunity, and disruption of leptin receptor signaling

We evaluated the susceptibility and lung responses of type 2 diabetic and lean mice following intranasal SARS-CoV-2 infection using the mouse-adapted MA10 strain Diabetic Leprdb mice and lean heterozygote mice were intranasally inoculated with 20,000 PFU of mouse-adapted SARS-CoV-2 MA10 strain and lungs were collected and processed for analysis at 2 and 4 days post-infection. Total RNA was isolated from homogenized lung and subjected to RNAseq