Crystal structure of RIP1 kinase in complex with a pyrrolidine
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Crystal structure of RIP1 kinase in complex with a pyrrolidine Descriptor: 1-[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one, Receptor-interacting serine/threonine-protein kinase 1, SULFATE ION Authors: Thorpe, J.H, Harris, P.A. Deposit date: 2019-03-25 Release date: 2019-05-08 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.793 Å) Cite: Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J.Med.Chem., 62, 2019
创建时间：
2019-03-25
