Human aldose reductase mutant L300P complexed with uracil-type inhibitor at 1.45 A.

Human aldose reductase mutant L300P complexed with uracil-type inhibitor at 1.45 A. Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID Authors: Steuber, H, Heine, A, Klebe, G. Deposit date: 2007-03-31 Release date: 2008-04-01 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. J.Mol.Biol., 379, 2008