Transcriptomic profiles of myometrial PGR deficient and control mouse uteri at gestation day 13

Progesterone signaling is crucial for pregnancy. To investigate the role of myometrial progesterone receptor in support of pregnancy, genome-wide gene expression profiles of pregnant uterine tissues from myometrial PGR knockout and control mice were profiled by RNAseq. The transcriptomic alterations in response to PGR loss permit identification of the underlying molecular mechanisms by which progesterone and PGR control myometrial homeostasis for pregnancy. Mouse uterine tissues surrounding the embryo implantation sites at gestation day 13 were subject to RNA-seq analysis.孕酮信号通路对于妊娠过程至关重要。为探究子宫肌层孕酮受体（progesterone receptor, PGR）在妊娠维持中的作用，研究人员通过RNA测序（RNA-seq）对子宫肌层PGR敲除与对照小鼠的妊娠子宫组织进行了全基因组基因表达谱分析。PGR缺失引发的转录组改变，可用于解析孕酮及PGR调控妊娠相关子宫肌层稳态的潜在分子机制。本数据集针对妊娠第13天胚胎着床位点周围的小鼠子宫组织开展了RNA-seq分析。