Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule

This repository contains the source data, analysis outputs, and metadata for “Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule.” Datasets span NMR (CSPs, PREs), dynamic light scattering, microscale thermophoresis, turbidity/c_sat, HPLC-based small-molecule partitioning, fluorescence/DIC microscopy, FRAP, and a cell-based LacI tethering assay. Raw instrument exports, processed tables (CSV/XLSX), images (TIFF/JPEG/LSM/CZI), and analysis scripts (Python/R) are provided with per-folder READMEs. Files are organized by figure/panel. Protein backbone NMR assignments are deposited in BMRB; accession numbers are listed in the repository README. No personally identifiable or sensitive data are included.
Intrinsically disordered regions (IDRs) are challenging drug targets because they lack stable interaction sites for drug-like molecules. We studied the first small molecule targeting an IDR to be evaluated in a clinical trial and found that ..., , # Data from: Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule

Dataset DOI: [10.5061/dryad.w9ghx3g3s](https://doi.org/10.5061/dryad.w9ghx3g3s)

## Description of the data and file structure

**Title:** Data for “Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule”

### Overview

Source data underlying Figures 1–6 and Supplementary Figures S1–S7, including NMR chemical shifts/CSPs and helix populations, DLS size distributions and monomer fractions, HPLC chromatograms, EPI-001 partitioning/ c_sat, FRAP quantifications and time-lapse imaging, PRE datasets, MST traces, and intact-MS adduct timecourses.

### File & folder structure

Files are organized by manuscript figures. Each ZIP contains raw exports and processed tables used to generate the corresponding panels.

* **Fig_1_EPI001_Selectivity_NRADs.zip** — NR AD sequence properties; per-residue CSPs of NR ADs ± EPI-001; EPI-001 ..., , **Changes after Dec 17, 2025:** 

The chemical shift for **ERα AD residue 81 (Gly, CO)** was corrected in **Fig_S1I_NR_ADs_helix_population_NMR_delta2D.xlsx** (in **SI_1_NRADs_SeqProps_NMR.zip**).