Sucrose challenge symptoms data

Our study addresses a significant diagnostic challenge in the field of gastroenterology – the diagnosis of Congenital Sucrase Isomaltase Deficiency (CSID). CSID is a genetic carbohydrate malabsorption disorder characterized by insufficient sucrase-isomaltase activity, resulting in chronic post-prandial gastrointestinal symptoms. CSID has historically been characterized as a pediatric condition primarily diagnosed through testing for disaccharidase activity in duodenal biopsies obtained during an esophagogastroduodenoscopy (EGD) examination. However, this invasive diagnostic method is not routinely used to diagnosis carbohydrate malabsorption in adults. Recent evidence indicates that CSID persists into adulthood, often escaping diagnosis during childhood. Notably, the diagnostic approach for CSID in adults remains underexplored, and there is a scarcity of published studies in this area.Diagnosis of CSID is difficult due to overlapping symptoms with other gastrointestinal disorders. One of the key strengths of our study is its real-world applicability. Instead of relying on invasive procedures or laboratory-based tests, we explored a simple and non-invasive approach. We asked CSID patients and healthy individuals to self-report the severity of gastrointestinal symptoms following a sucrose challenge, effectively simulating conditions that patients might experience at home. This approach provides valuable insights into symptomatology that are often missed in clinical settings. Our study addresses this gap by presenting the first comprehensive investigation into the diagnostic approach for CSID in adults. We believe that our findings offer valuable insights into the diagnosis of CSID in the adult population and contribute to a deeper understanding of this condition.