ELK3 modulates the antitumor efficacy of natural killer cells against triple negative breast cancer by regulating mitochondrial dynamics [ChIP-seq]

We demostrated that ELK3-Mid51 axis in TNBCs mediate mitochondrial dynamics determines concentration of reactive oxygen species that is linked to the immune sensitivity to cytotoxicity of NK cells. Overall design: To screen downstream targets of ELK3, ELK3KD-231 were transfected with pLenti-cMyc-Flag-ELK3. We performed chromatin immunoprecipitation assay using anti-Flag.