Data underlying the publication: Reduced prevalence of phage defense systems in Pseudomonas aeruginosa strains from cystic fibrosis patients

This dataset supports the study <em>“Reduced prevalence of phage defense systems in Pseudomonas aeruginosa strains from cystic fibrosis patients”</em> and contains data investigating the relationship between host-associated environments and bacterial antiviral defenses. The research objective was to compare the abundance and diversity of phage defense systems in <em>P. aeruginosa</em> isolates from cystic fibrosis (CF) patients versus environmental strains, in order to assess how long-term adaptation to the CF lung environment influences bacterial immunity. Data were collected through comparative genomics, and computational identification of defense system genes, complemented by experimental assays of phage susceptibility. The dataset includes defense system presence, phenotypes, and source information of each included strain in the analyses.

本数据集支撑题为<em>"囊性纤维化患者分离的铜绿假单胞菌（Pseudomonas aeruginosa）菌株中噬菌体（phage）防御系统检出率降低"</em>的研究，包含用于探究宿主相关环境与细菌抗病毒防御机制之间关联的数据。本研究的目标为对比囊性纤维化（CF）患者分离的铜绿假单胞菌菌株与环境菌株的噬菌体防御系统丰度与多样性，以评估长期适应CF肺部环境如何影响细菌免疫能力。数据通过比较基因组学、防御系统基因的计算鉴定方法获取，并辅以噬菌体易感性实验测定进行补充验证。本数据集包含本次分析中纳入的每一株菌株的防御系统存在情况、表型信息及菌株来源信息。