Intra- and inter-tumoral heterogeneity of liver metastases in a patient with uveal melanoma

Tumour heterogeneity has been the main obstacle to the clinical efficacy of targeted and immunotherapy in cancer. An accurate understanding and recognition of tumour heterogeneity is critical in the clinical management of cancer patients. Here, we utilised single-cell RNA sequencing (scRNA-seq) to uncover the intra- and inter-tumoural heterogeneity of liver metastases from a patient with metastatic uveal melanoma. Overall design: Single-cell RNA sequencing was performed on two liver metastases from a patient with uveal melanoma