ROLE OF HYALURONIC ACID IN PERIODONTAL BONE REGENERATION

Hyaluronic acid is a natural component of extra cellular matrix in both soft and hard periodontal tissues .Hyaluronic acid is located in both mineralised tissues (i.e cementum and alveolar bone) and non mineralised tissues (i.e gingiva and periodontal ligament) .Hyaluronic acid due to its anti-inflammatory ,anti -edematous ,anti- bacterial ,stimulation of angiogenic effects and osteoconductive effects has the potential to regulate periodontal tissue regeneration .Along with these properties , its role in modulation of wound healing makes it an adjunct to surgical and non surgical periodontal therapy.The use of Hyaluronic acid to treat periodontal bone defects has been shown to accelerate bone regeneration owing to its osteoconductive potential ,proliferation and differentiation of mesenchymal cells ,and regulating activities of osteoblast ,fibroblast ,cementoblast along with enhancement of osteogenetic effect of bone morphogenetic protein -2 in periodontal regeneration .This review examines the current literature favouring the use of hyaluronic acid in the regeneration of periodontal infrabony defects.