Postnatal day 1.5 small intestine transcriptome analysis in wild type and ASE-/- mice. Postnatal day 1.5 small intestine transcriptome analysis in wild type and ASE-/- mice

By comparing the small intestine transcriptomes of 4 wild type and 3 ASE-/- mice, we identified several oxidative balance related genes are exressed differentially between WT and ASE-/- in postnatal day 1.5 small intestine when dietary nutrient uptake became vital to support neonatal physiology. We here discover that the asymmetry enhancer of Pitx2 is critical for proper redox homeostasis.This is in agreement with the previous discovery that Pitx2 is important for cellular oxidative balance and is therefore important in cellular maturation and differentiation. Overall design: Intestine mRNA profiles of 1.5-day old wild type (WT) and ASE-/- mice