Supplemental dataset: Single nucleotide polymorphisms for creation of polygenic score for early childhood caries.

These data are those used to construct a polygenic score for early childhood caries, as originally provided by Haworth et al., and as used in Blostein et al. 2023 (unpublished). 

For each SNP in the final PGS used in Blostein et al. 2023, this dataset provide the identifier, chromosome, position, weight, and  P-value from the base data (available from  

https://data.bris.ac.uk/datasets/pkqcnil6e9ju2nyreblt3mvwf/summary_statistics/). 

The base data is a GWAS meta-analysis of 22 European-ancestry cohorts (base data, n=17,666 children) (Haworth et al. 2018). 

After quality-control, 6,044,259 SNPs overlapped between the base data and COHRA2 (Supplemental Methods). PGSs were calculated at 7 P-value thresholds: 0.001, 0.05, 0.1, 0.2, 0.3, 0.4 and 0.5. We selected the PGS with the best pseudo- R2  measures (Lee et al. 2012) in cross-sectional models regressing prevalent ECC against each PGS, child sex, and the first 5 genetic ancestry PCs. This was the PGS with P-value<0.001 used as cut off.