five

Cell Reports_DMD

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We aimed to determine the role of cardiac ion channels controlling cardiac excitability in the mechanisms of arrhythmias in DMD patients. Thus, we hypothesize that by disrupting the DAPC, the mutations in the dystrophin gene that lead to a truncation of the Dp427 dystrophin isoform, alter the functional expression of the most important cardiac ion channels controlling cardiac excitability and conduction velocity and leads to arrhythmogenesis and sudden cardiac death .
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2020-08-02
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