Identification of scavenger receptors and thrombospondin type 1 repeat proteins potentially relevant for plastid recognition in Sacoglossa

Functional kleptoplasty is a photosymbiotic relationship, in which photosynthetically active chloroplasts serve as an intracellular symbiont for a heterotrophic host. Among Metazoa, functional kleptoplasty is only found in marine sea slugs belonging to the Sacoglossa and recently described in rhabdocoel worms. Although functional kleptoplasty has been intensively studied in Sacoglossa, the fundamentals of the specific recognition of the chloroplasts and their subsequent incorporation are unknown. The key to ensure the initiation of any symbiosis is the ability to specifically recognize the symbiont and to differentiate a symbiont from a pathogen. For instance, in photosymbiotic cnidarians, several studies have shown that the host innate immune system, in particular scavenger receptors (SRs) and thrombospondin type 1 repeat protein superfamily (TSRs), is playing a major role in the process of recognizing and differentiating symbionts from pathogens. In the present study, SRs and TSRs of ...