five

Mapping the sequence-function landscape for quorum sensing specificity

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP444957
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The goal of this study is to increase the specificity of an allosteric transcription factor LasR. A combinatorial saturation mutagenesis library was introduced to LasR L125-L130 region. We then performed the pooled sort-seq approach to quantify corresponding sensor's response to cognate and noncognate signals.
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2023-06-21
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