RNA-sequencing of 7 weeks old mouse testes

We performed RNA-sequencing of testes derived from Atr+/+ or Atr+/KD 7 weeks old mice. Since Atr+/KD male mice are sterile and present severe spermatogenesis defects, we aimed at analyzing the possible changes in gene expression given by the ATR kinase-dead (KD) mutation. Evaluation of differential gene expression in Atr+/+ or Atr+/KD mice testes.我们对7周龄Atr+/+与Atr+/KD小鼠的睾丸组织开展了RNA测序（RNA-sequencing）。鉴于Atr+/KD雄性小鼠不育且存在严重的精子发生缺陷，本研究旨在探究ATR激酶失活（kinase-dead, KD）突变所引发的基因表达变化，并对Atr+/+与Atr+/KD小鼠睾丸组织中的差异基因表达进行分析评估。