Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish. Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish

To investigate contribution of different UPR pathways to ER stress-induced abnormal heart phenotype in medaka, we generated constitutive XBP1(S) or ATF6(N) expression medaka lines. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different genotype medaka hearts. Overall design: Comparative gene expression profiling analysis of RNA-seq data for AXER+/+, AXER-/-, AXER-/- +XBP1(S), and AXER-/- +ATF6(N)