Calycosin as a novel PI3K activator reduces inflammation and fibrosis in heart failure through AKT-IKK/STAT3 axis

Conclusion: Cal improves cardiac function against HF by inhibiting cardiomyocytes inflammation and fibroblasts fibrosis via activation of the PI3K-AKT pathway.结论：Cal可通过激活磷脂酰肌醇3-激酶-蛋白激酶B（PI3K-AKT）通路，抑制心肌细胞炎症反应与成纤维细胞纤维化，从而改善心力衰竭（Heart Failure, HF）的心脏功能。